INVESTIGACIÓN

1991

Artículos

Arenas J, Ricoy JR, Encinas AR, Pola P, D’Iddio S, Zeviani M, et al. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. Muscle Nerve. 1991;14(7):598-604

Fernández B, Balsinde J. Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. Biochem Biophys Res Commun. 1991;180(2):1036-40

Landa García I, Arias Díaz J, Gómez Gutiérrez M, Ortega Medina L, Llanos K, Martos A, et al. -Efecto de la somatostatina sobre la supervivencia y los niveles de PGE:2) en un modelo de pancreatitis aguda necrohemorragica en el perro. Gastroenterol Hepatol. 1991;14(9):481-7

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1992

Artículos

Balsinde J, Fernández B, Solís Herruzo JA, Diez E. Pathways for arachidonic acid mobilization in zymosan-stimulated mouse peritoneal macrophages. Biochim Biophys Acta. 1992;1136(1):75-82.

Fernández B, Solís Herruzo JA, Balsinde J. Mouse peritoneal macrophages contain an acylating system specific for twenty-carbon polyunsaturated fatty acids. A study with intact cells. Eicosanoids. 1992;5(2):115-20.

Huertas R, Campos Y, Díaz E, Esteban J, Vechietti L, Montanari G, et al. Respiratory chain enzymes in muscle of endurance athletes: effect of L-carnitine. Biochem Biophys Res Commun. 1992;188(1):102-7.

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1993

Artículos

Balsinde J. Mechanism of arachidonic acid liberation in ethanol-treated mouse peritoneal macrophages. Biochim Biophys Acta. 1993 21;1169(1):54-8.

Campos Y, Huertas R, Bautista J, Gutiérrez E, Aparicio M, Lorenzo G, et al. Muscle carnitine deficiency and lipid storage myopathy in patients with mitochondrial myopathy. Muscle Nerve. 1993;16(7):778-81.

Campos Y, Huertas R, Lorenzo G, Bautista J, Gutiérrez E, Aparicio M, et al. Plasma carnitine insufficiency and effectiveness of L-carnitine therapy in patients with mitochondrial myopathy. Muscle Nerve. 1993;16(2):150-3.

Fernández B, Balsinde J. Calcium- and G-protein-dependent activation of arachidonic acid release by concanavalin-A-stimulated mouse macrophages. Biochim Biophys Acta. 1993;1176(1-2):169-74

Trueba JL, Gutiérrez Rivas E, Arenas J, Cabello A. Miopatías mitocondriales. An Med Interna. 1993;10 Suppl:21-7

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1994

Artículos

Arenas J, Huertas R, Campos Y, Díaz AE, Villalón JM, Vilas E. Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyl transferase activities in muscle of endurance athletes. FEBS Lett. 1994;341(1):91-3.

Balsinde J, Fernández B, Solís Herruzo JA. Increased incorporation of arachidonic acid into phospholipids in zymosan-stimulated mouse peritoneal macrophages. Eur J Biochem. 1994;221(3):1013-8.

Balsinde J, Fernández B, Solís Herruzo JA. Ethanol inhibits zymosan-stimulated eicosanoid production in mouse peritoneal macrophages. Biochim Biophys Acta. 1994;1210(2):195-201

Campos Y, Bautista J, Gutiérrez Rivas E, Llabrés J, Lorenzo G, Arenas J. Variable clinical expression associated with the mutation 3243 np of mitochondrial DNA. J Inherit Metab Dis. 1994;17(5):634-5

Fernández B, Balboa MA, Solís Herruzo JA, Balsinde J. Phosphatidate-induced arachidonic acid mobilization in mouse peritoneal macrophages. J Biol Chem. 1994;269(43):26711-6

Gómez Reino JJ, Aznar JJ, Pablos JL, Díaz González F, Laffón A. Nontropical pyomyositis in adults. Semin Arthritis Rheum. 1994;23(6):396-405

Hernández Muñoz I, De la Torre MP, Pedraza MA, Sánchez Alcázar JA, Muñoz Yagüe MT, Solís Herruzo JA. Toxic oil stimulates collagen synthesis acting at a pretranslational level in cultured fat-storing cells. Gastroenterology. 1994;106(3):691-701

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1995

Artículos

Campos Y, Bautista J, Gutiérrez Rivas E, Chinchón D, Cabello A, Segura D, et al. Clinical heterogeneity in two pedigrees with the 3243 bp tRNA(Leu(UUR)) mutation of mitochondrial DNA. Acta Neurol Scand. 1995;91(1):62-5

Campos Y, García Silva T, Barrionuevo CR, Cabello A, Muley R, Arenas J. Mitochondrial DNA deletion in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes (MELAS) and Fanconi’s syndrome. Pediatr Neurol. 1995 Jul;13(1):69-72 [doi]

Landa JI, Alvarez Sánchez J, Grau M, Sánchez JA, Balibrea JL. Somatostatin reduces the levels of tumor necrosis factor alpha in a rat model of endotoxemia induced by lipopolysaccharide. Res Exp Med (Berl). 1995;195(5):317-25 [doi]

Sánchez Alcázar JA, Hernández I, De la Torre MP, García I, Santiago E, Muñoz-Yagüe MT, et al. Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. J Biol Chem. 1995 Oct 13;270(41):23944-50 [doi

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1996

Artículos

Arenas J, González Crespo MR, Campos Y, Martín MA, Cabello A, Gómez Reino JJ. Abnormal carnitine distribution in the muscles of patients with idiopathic inflammatory myopathy. Arthritis Rheum. 1996;39(11):1869-74.

Campos Y, Martín MA, Lorenzo G, Aparicio M, Cabello A, Arenas J. Sporadic MERRF/MELAS overlap syndrome associated with the 3243 tRNA(Leu(UUR)) mutation of mitochondrial DNA. Muscle Nerve. 1996;19(2):187-90.

Campos Y, Martín MA, Navarro C, Gordo P, Arenas J. Single large-scale mitochondrial DNA deletion in a patient with mitochondrial myopathy associated with multiple symmetric lipomatosis. Neurology. 1996;47(4):1012-4.

Campos Y, Martín MA, Rubio JC, Ricard C, Cabello A, Arenas J. Multiple deletions of mitochondrial DNA in muscle from a patient with benign progressive external ophthalmoplegia. J Inherit Metab Dis. 1996;19(3):366-7.

Campos Y, Martín MA, Vaamonde J, Cabello A, Esteban J, Arenas J. Clinical variability associated with the mutation at nucleotide position 8344 of the mitochondrial DNA. J Inherit Metab Dis. 1996;19(2):119-22.

De los Reyes B, Pérez García R, Liras A, Arenas J. Reduced carnitine palmitoyl transferase activity and altered acyl-trafficking in red blood cells from hemodialysis patients. Biochim Biophys Acta. 1996;1315(1):37-9.

Gabriel Sánchez R, Gómez de la Cámara A. Métodos de investigación en cardiología clínica (I): Tipos de diseños básicos. Estudios observacionales en cardiología clínica (I). Rev Esp Cardiol. 1996;49(11):837-51

Gómez PA, Díez Lobato R, Ortega JM, De la Cruz J. Mild head injury: differences in prognosis among patients with a Glasgow Coma Scale score of 13 to 15 and analysis of factors associated with abnormal CT findings. Br J Neurosurg. 1996;10(5):453-60

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1997

Artículos

Cabello López JB, Pozo Rodríguez P. Métodos de investigación en cardiología clínica (X): Estudios de evaluación de las pruebas diagnósticas en cardiología. Rev Esp Cardiol. 1997;50(7):507-19.

Campos Y, Martín MA, Rubio JC, Gutiérrez del Olmo MC, Cabello A, Arenas J. Bilateral striatal necrosis and MELAS associated with a new T3308C mutation in the mitochondrial ND1 gene. Biochem Biophys Res Commun. 1997;238(2):323-5

Fernández I, Castellano G, Domingo MJ, Fuertes A, Colina F, Canga F, et al. Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy inSpanish patients with chronic C infection. Scand J Gastroenterol. 1997;32(1):70-6

García Pascual J, Urbina Fuentes J. Hipertiroidismo e insuficiencia tricúspide. Rev Esp Cardiol. 1997;50(7):539.

Gómez de la Cámara A, Ciruelo Monge E, De la Cruz Bértolo J, Serrano Díaz JM, Pato Cour E, Gómez-Reino Carnota JJ. Pérdida de fiabilidad en la extracción de datos de las historias clínicas: origen de los defectos y utilidad del adiestramiento. Med Clin (Barc). 1997;108(10):377-81.

Gómez de la Cámara A, Cruz Martos E, De la Cruz Bértolo J, Landa Goñi J, Guillomía Contreras S, Aurrecoechea R. Análisis de la fiabilidad de tres dosímetros portátiles de glucemia. Comparación de diferentes métodos para el estudio de la fiabilidad de las observaciones clínicas. Med Clin (Barc). 1997;108(11):410-3

Hernández Muñoz I, De la Torre P, Sánchez Alcázar JA, García I, Santiago E, Muñoz Yagüe MT, et al. Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein. Gastroenterology. 1997;113(2):625-40

Pablos JL, Carreira PE, Serrano L, Del Castillo P, Gómez Reino JJ. Apoptosis and proliferation of fibroblasts during postnatal skin development and scleroderma in the tight-skin mouse. J Histochem Cytochem. 1997 May;45(5):711-9 [doi]

Rubio JC, Martín MA, Bautista J, Campos Y, Segura D, Arenas J. Association of genetically proven deficiencies of myophosphorylase and AMP deaminase: a second case of ‘double trouble’. Neuromuscul Disord. 1997;7(6-7):387-9.

Sánchez Alcázar JA, Ruíz Cabello J, Hernández Muñoz I, Pobre PS, De la Torre P, Siles-Rivas E, et al. Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death. J Biol Chem. 1997;272(48):30167-77.

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1998

Artículos

Arenas J, Campos Y, Ribacoba R, Martín MA, Rubio JC, Ablanedo P, et al. Complex I defect in muscle from patients with Huntington’s disease. Ann Neurol. 1998;43(3):397-400.

Arenas J, Rubio JC, Martín MA, Campos Y. Biological roles of L-carnitine in perinatal metabolism. Early Hum Dev. 1998;53 Suppl:S43-50

Bermejo M, Martín Serrano J, Oberlin E, Pedraza MA, Serrano A, Santiago B, et al. Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains. Eur J Immunol. 1998;28(10):3192-204

Calandre L, Grau M, Álvarez J, Rabasa M, Ruiz J, Hernández Lain A. Early complete recanalization in internal carotid artery embolism treated with high-dose t-PA: a sequential angiographic study in a novel model of embolism in rats. J Neurol Sci. 1998;157(1):19-24

Campos Y, Martín MA, García Silva T, Del Hoyo P, Rubio JC, Castro Gago M, et al. Clinical heterogeneity associated with mitochondrial DNA depletion in muscle. Neuromuscul Disord. 1998;8(8):568-73.

De los Reyes B, Navarro JA, Pérez García R, Liras A, Campos Y, Bornstein B, et al. Effects of L-carnitine on erythrocyte acyl-CoA, free CoA, and glycerophospholipid acyltransferase in uremia. Am J Clin Nutr. 1998;67(3):386-90.

Íñiguez MA, Pablos JL, Carreira PE, Cabré F, Gómez Reino JJ. Detection of COX-1 and COX-2 isoforms in synovial fluid cells from inflammatory joint diseases. Br J Rheumatol. 1998;37(7):773-8.

Martín MA, Campos Y, De Bustos F, Del Hoyo P, Rubio JC, Arenas J. Genética molecular de las alteraciones de la cadena respiratoria mitocondrial. Rev Neurol. 1998;26 Suppl 1:S27-35.

Martín Serrano J, Folgueira L, Laín de Lera T, Pedraza MA, Lemichez E, Sánchez Palomino S, et al. In vitro selective elimination of HIV-infected cells from peripheral blood in AIDS patients by the immunotoxin DAB389CD4. AIDS. 1998;12(8):859-63.

Moreira Andrés MN, Cañizo FJ, De la Cruz FJ, Gómez de la Cámara A, Hawkins FG. Bone mineral status in prepubertal children with constitutional delay of growth and puberty. Eur J Endocrinol. 1998;139(3):271-5

Ortiz de Frutos FJ, Guerra Tapia A, Gómez de la Cámara A, De la Cruz Bertolo J, Álvarez Fernández JG, De la Mano Orejón D. Validación de la versión española del cuestionario diagnóstico del Grupo de Trabajo sobre la Dermatitis Atópica del Reino Unido. Rev Clin Esp. 1998;198(7):424-8

Rubio JC, Martín MA, Bautista J, Campos Y, Segura D, Cabello A, et al. Myophosphorylase deficiency associated with a defect in complex I of the mitochondrial respiratory chain. J Neurol Sci. 1998;161(2):110-3.

Rubio JC, Martín MA, Del Hoyo P, De Bustos F, Campos Y, Arenas J. Déficits de los complejos enzimáticos de la cadena respiratoria mitocondrial. Rev Neurol. 1998;26 Suppl 1:S15-20.

Ruiz Pesini E, Díez C, Lapeña AC, Pérez Martos A, Montoya J, Álvarez E, et al. Correlation of sperm motility with mitocondrial enzymatic activities. Clin Chem. 1998;44(8 Pt 1):1616-20.

Solís Herruzo JA, Hernández I, De la Torre P, García I, Sánchez JA, Fernández I, et al. G proteins are involved in the suppression of collagen alpha 1 (I) gene expression in cultured rat hepatic stellate cells. Cell Signal. 1998;10(3):173-83.

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1999

Artículos

Arenas J, Campos Y, Bornstein B, Ribacoba R, Martín MA, Rubio JC, Santorelli FM, Zeviani M, DiMauro S, Garesse R. A double mutation (A8296G and G8363A) in the mitochondrial DNA tRNA (Lys) gene associated with myoclonus epilepsy with ragged-red fibers. Neurology. 1999;52(2):377-82

Ayerbe J, Díez Lobato R, De la Cruz J, Alday R, Rivas JJ, Gómez PA, Cabrera A. Risk factors predicting recurrence in patients operated on for intracranial meningioma. A multivariate analysis. Acta Neurochir (Wien). 1999;141(9):921-32

De la Cruz Bértolo FJ, Pallás Alonso CR, Tejada Palacios P. Cribado para la retinopatía de la prematuridad: ni son todos los que están, ni están todos los que son. An Esp Pediatr. 1999;50(2):156-60.

Fernández Miranda C, Aranda JL, Gómez González P, Díaz Rubio P, Estenoz J, Gómez de la Cámara A. La hiperhomocisteinemia es frecuente en pacientes con enfermedad coronaria. Estudio de 202 enfermos. Med Clin (Barc). 1999;113(11):407-10.

Gómez de la Cámara A. Tipos de estudios de investigación clínica: errores más importantes en su diseño e interpretación. Arch Bronconeumol. 1999;35 Suppl 1:9-13

Gómez PA, Díez Lobato R, González P, Boto GR, De la Lama A, De la Cruz FJ.  Trauma craneal grave. Base datos Hospital 12 de Octubre. I descripción base datos. Evolución final. Neurocirugía. 1999;10(4):297-308

Laín de Lera T, Folgueira L, Martín AG, Dargemont C, Pedraza MA, Bermejo M, Bonay P, Fresno M, Alcami J. Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes. Oncogene. 1999;18(8):1581-8.

Martín MA, Campos Y, García Silva MT, Rubio JC, Del Hoyo P, De Bustos F, García A, Arenas J. Slow segregation and rapid shift to homoplasmy coexist in a family with the T8993 > G mutation. J Inherit Metab Dis. 1999;22(8):939-40

Martín MA, Rubio JC, De Bustos F, Del Hoyo P, Campos Y, García A, Börnstein B, Cabello A, Arenas J. Molecular analysis in Spanish patients with muscle carnitine palmitoyltransferase deficiency. Muscle Nerve. 1999;22(7):941-3

Morales Gutiérrez C, Vegh I, Colina F, Gómez Cámara A, Ignacio Landa J, Ballesteros D, Carreira PE, Enríquez de Salamanca R. Survival of patients with colorectal carcinoma: possible prognostic value of tissular carbohydrate antigen 19.9 determination. Cancer. 1999;86(9):1675-81

Pablos JL, Amara A, Bouloc A, Santiago B, Caruz A, Galindo M, Delaunay T, Virelizier JL, Arenzana Seisdedos F. Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am J Pathol. 1999;155(5):1577-86

Pedraza MA, Del Romero J, Roldán F, García S, Ayerbe MC, Noriega AR, Alcamí J. Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner. J Acquir Immune Defic Syndr. 1999;21(2):120-5

Rubio JC, Martín MA, García A, Campos Y, Cabello A, Culebras JM, Arenas J. McArdle’s disease associated with homozygosity for the missense mutation Gly204Ser of the myophosphorylase gene in a Spanish patient. Neuromuscul Disord. 1999;9(3):174-5

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2000

Artículos

Ballesteros Pomar MD, Rubio Herrera MA, Gutiérrez Fuentes JA, Gómez Gerique JA, Gómez de la Cámara A, Pascual O, et al. Dietary habits and cardiovascular risk in the Spanish population: the DRECE study (I). Diet and Cardiovascular Events Risk in Spain. Ann Nutr Metab. 2000;44(3):108-14 [doi

Campos Y, Lorenzo G, Martín MA, Torregrosa A, Del Hoyo P, Rubio JC, García A, Arenas J. A mitochondrial tRNA(Lys) gene mutation (T8316C) in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes. Neuromuscul Disord. 2000;10(7):493-6 [doi]

Campos Y, Martín MA, Caballero C, Rubio JC, De la Cruz F, Tuñón T, Arenas J. Single large-scale mitochondrial DNA deletion in a patient with encephalopathy, cardiomyopathy, and prominent intestinal pseudo-obstruction. Neuromuscul Disord. 2000;10(1):56-8

Del Palacio A, Sanz F, Sánchez Alor G, Garau M, Calvo MT, Boncompte E, Algueró M, Pontes C, Gómez de la Cámara A. Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream. Mycoses. 2000;43(9-10):355-65

Fontanellas A, Mazurier F, Landry M, Taine L, Morel C, Larou M, et al. Reversion of hepatobiliary alterations By bone marrow transplantation in a murine model of erythropoietic protoporphyria. Hepatology. 2000;32(1):73-81 [doi]

Gil J, Alcamí J, Esteban M. Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex. Oncogene. 2000;19(11):1369-78 [doi

Gómez de la Cámara A, Navarro Gil P, Grandes Velasco S, Ortega Fraile MA, Jurado Valenzuela C, Gómez Medina MA. Intervenciones médicas no farmacológicas basadas en la evidencia. Estudio exploratorio. Med Clin (Barc). 2000;114 Suppl 2:85-7

Gómez de la Cámara A, Nemery B. Epidemias, histeria colectiva y desinformación. Rev Med Fam Comunitaria. 2000;10(6):331-3

Hernández I, De la Torre P, Rey Campos J, García I, Sánchez JA, Muñoz R, Rippe RA, Muñoz Yagüe T, Solís Herruzo JA. Collagen alpha1(I) gene contains an element responsive to tumor necrosis factor-alpha located in the 5′ untranslated region of its first exon. DNA Cell Biol. 2000;19(6):341-52.

Lagartera L, Fontanellas A, Muñoz Ribero MC, Navarro S, Enríquez de Salamanca R. Aproximación de laboratorio al diagnóstico y tipificación de una porfiria. An Med Interna. 2000;17(11):609-13

López Valdés E, Hernández Laín A, Calandre L, Grau M, Cabello A, Gómez Escalonilla C. Time window for clinical effectiveness of mass evacuation in a rat balloon model mimicking an intraparenchymatous hematoma. J Neurol Sci. 2000;174(1):40-6 [doi

Martín MA, Gómez MA, Guillén F, Börnstein B, Campos Y, Rubio JC, De la Calzada CS, Arenas J. Myocardial carnitine and carnitine palmitoyltransferase deficiencies in patients with severe heart failure. Biochim Biophys Acta. 2000;1502(3):330-6.

Martín MA, Rubio JC, Campos Y, Ricoy JR, Cabello A, Arenas J. A homozygous missense mutation (A659D) in the myophosphorylase gene in a Spanish patient with McArdle’s disease. Neuromuscul Disord. 2000;10(6):447-9.

Martín MA, Rubio JC, Campos Y, Vílchez J, Cabello A, Arenas J. Two homozygous mutations (R193W and 794/795 delAA) in the myophosphorylase gene in a patient with McArdle’s disease. Hum Mutat. 2000;15(3):294.

Martín MA, Rubio JC, Del Hoyo P, García A, Bustos F, Campos Y, Cabello A, Culebras JM, Arenas J. Identification of novel mutations in Spanish patients with muscle carnitine palmitoyltransferase II deficiency. Hum Mutat. 2000;15(6):579-80

Moreira Andrés MN, Cañizo FJ, De la Cruz FJ, Gómez de la Cámara A, Hawkins FG. Evaluation of radial bone mineral content in prepubertal children with constitutional delay of growth. J Pediatr Endocrinol Metab. 2000;13(6):591-7

Muñoz DG, Ganapathy GR, Eliasziw M, Hachinski V. Educational attainment and socioeconomic status of patients with autopsy-confirmed Alzheimer disease. Arch Neurol. 2000;57(1):85-9 [doi

Rodríguez J, Fernández Crespo J, Lopez Rubio A, De La Cruz Bértolo J, Ferrando Vivas P, Vives R, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol. 2000;106(1 Pt 1):183-9 [doi]

Rubio JC, Martín MA, Campos Y, Auciello R, Cabello A, Arenas J. A missense mutation W797R in the myophosphorylase gene in a Spanish patient with McArdle’s disease. Muscle Nerve. 2000;23(1):129-31

Rubio JC, Martín MA, Campos Y, Cabello A, Arenas J. A missense mutation T487N in the myophosphorylase gene in a Spanish patient with McArdle’s disease. Neuromuscul Disord. 2000;10(2):138-40

Rubio JC, Martín MA, Del Hoyo P, Bautista J, Campos Y, Segura D, et al. Molecular analysis of Spanish patients with AMP deaminase deficiency. Muscle Nerve. 2000;23(8):1175-8 [doi

Ruiz Solís S, Mingote C, Gozalo A, Fernández Salas MJ, Varela P, Gómez de la Cámara A. Aproximación neurobiológica al trastorno de estrés postraumático. Arch Psiquiatr. 2000;63(3):221-40

Sánchez Alcázar JA, Schneider E, Martínez MA, Carmona P, Hernández Muñoz I, Siles E, De la Torre P, Ruiz Cabello J, García I, Solís Herruzo JA. Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells. J Biol Chem. 2000;275(18):13353-61

Woulfe J, Muñoz D. Tubulin immunoreactive neuronal intranuclear inclusions in the human brain. Neuropathol Appl Neurobiol. 2000;26(2):161-71 [doi